Journal
JOURNAL OF NEUROSCIENCE
Volume 35, Issue 41, Pages 13843-13852Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2775-15.2015
Keywords
Down syndrome; intellectual disability; brain abnormalities; mouse models; preventive therapies
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Down syndrome (DS) is a relatively common genetic condition caused by the triplication of human chromosome 21. No therapies currently exist for the rescue of neurocognitive impairment in DS. This review presents exciting findings showing that it is possible to restore brain development and cognitive performance in mouse models of DS with therapies that can also apply to humans. This knowledge provides a potential breakthrough for the prevention of intellectual disability in DS.
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