Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 19, Issue 2, Pages 174-180Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2009.04.011
Keywords
-
Categories
Funding
- NIH [R01 EY014689, R01 EY015231]
Ask authors/readers for more resources
Visual system development utilizes global and local cues to assemble a topographic map of the visual world, arranging synaptic connections into columns and layers. Recent genetic studies have provided new insights into the mechanisms that underlie these processes. In flies, a precise temporal sequence of neural differentiation provides a global organizing cue; in vertebrates, gradients of ephrin-mediated signals, acting with neurotrophin co-receptors and neural activity, play crucial roles. In flies and mice, neural processes tile into precise arrays through homotypic, repulsive interactions, autocrine signals, and cell-intrinsic mechanisms. Laminar targeting specificity is achieved through temporally regulated cell-cell adhesion, as well as combinatorial expression of specific adhesion molecules. Future studies will define the interactions between these global and local cues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available