Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 18, Issue 5, Pages 495-503Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2008.10.003
Keywords
-
Categories
Funding
- NIH RO1 [MH075058, GM069808]
- NRSA
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM069808] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH075058] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The mechanisms for delivering components to nerve terminals are diverse and highly regulated. The diversity of kinesin motors alone is insufficient to account for the specificity of delivery. Additional specificity and control are contributed by adaptor proteins and associated regulatory molecules. The interaction of cargos with these complexes can confer distinct behaviors on the transport of synaptic organelles. The rich regulatory mechanisms of transport that are only now emerging as the cargo-motor complexes are defined and subsequent local events that regulate their dynamic relationship are examined. Here we review recent studies of kinesin-related axonal transport of three crucial synaptic components, Piccolo-bassoon Transport Vesicles (PTVs), Synaptic Vesicle Precursors (SVPs), and mitochondria, and the mechanisms that modulate their transport.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available