Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 18, Issue 3, Pages 284-291Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2008.07.013
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Funding
- Spinal Muscular Atrophy Foundation
- Claire and Leonard Tow Charitable Foundation
- New York State Office of Science Technology and Academic Research
- Centre National de la Recherche Scientifique
- European Union
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Cell death plays an important role both in shaping the developing nervous system and in neurological disease and traumatic injury. In spite of their name, death receptors can trigger either cell death or survival and growth. Recent studies implicate five death receptors - Fas/CD95, TNFR1 (tumor necrosis factor receptor-1), p75(NTR) (p75 neurotrophin receptor), DR4, and DR5 (death receptors-4 and -5) - in different aspects of neural development or degeneration. Their roles may be neuroprotective in models of Parkinson's disease, or pro-apoptotic in ALS and stroke. Such different outcomes probably reflect the diversity of transcriptional and post-translational signaling pathways downstream of death receptors in neurons and glia.
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