Journal
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Volume 20, Issue 1, Pages 56-61Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MNH.0b013e3283414c88
Keywords
chronic kidney disease; diabetic nephropathy; end-stage kidney disease; epithelial cells; fibrosis; glomerulus; Notch signaling; podocytes
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Funding
- National Institutes of Health [5R01DK076077-04]
- Juvenile Diabetes Research Foundation
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK076077] Funding Source: NIH RePORTER
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Purpose of review The Notch pathway is an evolutionary conserved cell-cell communication mechanism that plays a key role in kidney development. Here, we will discuss a number of recently published papers describing the role of Notch signaling in kidney development, homeostasis, injury and repair. Recent findings Recent gene expression studies identified regulation of the Notch pathway in patients with chronic kidney disease (CKD). Mechanistic experiments performed using transgenic and knock-out mouse models indicate that Notch plays an important functional role in the development of proteinuria and renal fibrosis. Inhibition of the Notch pathway ameliorated diabetic kidney disease, nephrotic syndrome and fibrosis in different rodent models. Summary An increasing amount of evidence suggests that Notch plays a role in CKD development. Understanding the role of Notch signaling in the kidney can aid in the development of new therapeutics for CKD.
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