Journal
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
Volume 19, Issue 1, Pages 43-50Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MNH.0b013e3283328eed
Keywords
chronic kidney diseases; hypoxia; hypoxia-inducible factor-1 alpha
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Funding
- Japan Society for the Promotion of Science [19390228, 20890053]
- Grants-in-Aid for Scientific Research [21591020] Funding Source: KAKEN
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Purpose of review Tubulointerstitial hypoxia in the kidney has been considered a hallmark of injury and mediator of disease progression. This review focuses on hypoxia-inducible factor (HIF)-1, a master transcription factor in cellular adaptation to hypoxia. Recent findings HIF-1 alpha is expressed in the hypoxic tubular epithelium as well in as the papillary interstitium and glomerular epithelial cells. Although HIF-1 plays a protective role in a number of acute kidney injury models when overexpressed, its activation in chronic kidney disease results in multiple phenotypic changes, depending on the pathological context. Summary Hypoxia, especially HIF-1, is a critical mediator in the pathogenesis of chronic kidney disease. Underlying molecular mechanisms, together with responsible HIF target genes, are currently under investigation.
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