Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 20, Issue -, Pages 69-75Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.05.005
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Funding
- Swiss National Science Foundation [310030_149784]
- Deutsche Forschungsgemeinschaft [SPP 1596]
- Swiss National Science Foundation (SNF) [310030_149784] Funding Source: Swiss National Science Foundation (SNF)
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An essential function of innate immunity is to distinguish self from non-self and receptors have evolved to specifically recognize viral components and initiate the expression of antiviral proteins to restrict viral replication. Coronaviruses are RNA viruses that replicate in the host cytoplasm and evade innate immune sensing in most cell types, either passively by hiding their viral signatures and limiting exposure to sensors or actively, by encoding viral antagonists to counteract the effects of interferons. Since many cytoplasmic viruses exploit similar mechanisms of innate immune evasion, mechanistic insight into the direct interplay between viral RNA, viral RNA-processing enzymes, cellular sensors and antiviral proteins will be highly relevant to develop novel antiviral targets and to restrict important animal and human infections.
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