Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 16, Issue 3, Pages 255-261Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.06.003
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Funding
- Vitagora Competitive Cluster
- French FUI (Fond Unique Interministeriel
- FUI) [F1010012D]
- FEDER (Fonda Europeen de Developpement Regional
- Bourgogne) [34606]
- Burgundy Region
- Conseil General 21
- Grand Dijon
- Merck Medication Familiale (Dijon, France)
- Biovitis (Saint Etienne de Chomeil, France)
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Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.
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