Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 16, Issue 6, Pages 708-715Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.09.006
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Funding
- Burroughs Wellcome Fund
- Pew Charitable Trust
- NIH [R21AI099659-01]
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Candida albicans is a fungal commensal-pathogen that persistently associates with its mammalian hosts. Between the commensal and pathogenic lifestyles, this microorganism inhabits host niches that differ markedly in the levels of bioavailable iron. A number of recent studies have exposed C. albicans specializations for acquiring iron from specific host molecules in regions where iron is scarce, while also defending against iron-related toxicity in regions where iron occurs in surfeit. Together, these results point to a central role for iron homeostasis in the evolution of this important human pathogen.
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