Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 16, Issue 3, Pages 355-365Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.05.003
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Funding
- NCATS NIH HHS [UL1 TR000041, UL1 TR001449] Funding Source: Medline
- NIAID NIH HHS [R37 AI042999, R01 AI042999] Funding Source: Medline
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The now well-accepted innate immunity paradigm that autophagy acts as a cell-autonomous defense against intracellular bacteria has its key origins in studies with Mycobacterium tuberculosis, an important human pathogen and a model microorganism infecting macrophages. A number of different factors have been identified that play into the anti-mycobacterial functions of autophagy, and recent in vivo studies in the mouse model of tuberculosis have uncovered additional anti-inflammatory and tissue-sparing functions of autophagy. Complementing these observations, genome wide association studies indicate a considerable overlap between autophagy, human susceptibility to mycobacterial infections and predisposition loci for inflammatory bowel disease. Finally, recent studies show that autophagy is an important regulator and effector of IL-1 responses, and that autophagy intersects with type I interferon pathology-modulating responses.
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