Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 16, Issue 3, Pages 246-254Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2013.07.002
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Funding
- EU-FP7 METACARDIS [HEALTH-F4-2012-305312]
- Nestle
- Institut Merieux
- EU-FP7 (METACARDIS)
- Scottish Government (RESAS)
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The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.
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