Journal
JOURNAL OF NEUROSCIENCE
Volume 35, Issue 36, Pages 12366-12382Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4715-14.2015
Keywords
blindness; cortical maps; fMRI; resting state; retinotopy; visual deprivation
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Funding
- National Institutes of Health [R01 EY014645]
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Early visual areas have neuronal receptive fields that form a sampling mosaic of visual space, resulting in a series of retinotopic maps in which the same region of space is represented in multiple visual areas. It is not clear to what extent the development and maintenance of this retinotopic organization in humans depend on retinal waves and/or visual experience. We examined the corticocortical receptive field organization of resting-state BOLD data in normally sighted, early blind, and anophthalmic (in which both eyes fail to develop) individuals and found that resting-state correlations between V1 and V2/V3 were retinotopically organized for all subject groups. These results show that the gross retinotopic pattern of resting-state connectivity across V1-V3 requires neither retinal waves nor visual experience to develop and persist into adulthood.
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