Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 14, Issue 1, Pages 92-98Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2010.12.012
Keywords
-
Categories
Funding
- NIAID NIH HHS [F32 AI085761-01] Funding Source: Medline
Ask authors/readers for more resources
Residing within the intestine is a large community of commensal organisms collectively termed the microbiota. This community generates a complex nutrient environment by breaking down indigestible food products into metabolites that are used by both the host and the microbiota. Both the invading intestinal pathogen and the microbiota compete for these metabolites, which can shape both the composition of the flora, as well as susceptibility to infection. After infection is established, pathogen mediated inflammation alters the composition of the microbiota, which further shifts the makeup of metabolites in the gastrointestinal tract. A greater understanding of the interplay between the microbiota, the metabolites they generate, and susceptibility to enteric disease will enable the discovery of novel therapies against infectious disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available