Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 13, Issue 2, Pages 168-176Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2010.01.013
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Funding
- NIH [GM-058746, VA 1I01BX000372]
- RCE in Mechanobiology, National University of Singapore
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In two-component signaling systems, phosphorylated response regulators (RRs) are often dephosphorylated by their partner kinases in order to control the in vivo concentration of phospho-RR (RR similar to P). This activity is easily demonstrated in vitro, but these experiments have typically used very high concentrations of the histidine kinase (HK) compared to the RR similar to P. Many two-component systems exhibit exquisite control over the ratio of HK to RR in vivo. The question thus arises as to whether the phosphatase activity of HKs is significant in vivo. This topic will be explored in the present review.
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