Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 13, Issue 4, Pages 392-400Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2010.05.001
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Funding
- German Federal Ministry of Education and Research
- EU [214004]
- Jena School for Microbial Communication (JSMC)
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Pathogenic yeasts, either from the environment or the normal flora, have to face phagocyte cells that constitute the first line of defence during infection. In order to evade or counteract attack by phagocytes, pathogenic yeasts have acquired a repertoire of strategies to survive, colonize and infect the host. In this review we focus on the interaction of yeasts, such as Candida, Histoplasma or Cryptococcus species, with macrophages or neutrophils. We discuss strategies used by these fungi to prevent phagocytosis or to counteract phagocyte activities. We go on to describe the strategies that permit intracellular survival within phagocytes and that may eventually lead to damage of and escape from the phagocyte
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