Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 13, Issue 3, Pages 344-349Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2010.03.003
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Funding
- National Institutes of Health [R01 GM057089]
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Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.
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