Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 13, Issue 2, Pages 219-225Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2009.12.011
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Funding
- NIH [GM072285]
- Office of Biological and Environmental Research in the DOE Office of Science
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM072285] Funding Source: NIH RePORTER
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Two-component signal transduction systems are abundant in prokaryotes. They enable cells to adjust multiple cellular functions in response to changing environmental conditions. These systems are also found, although in much smaller numbers, in lower eukaryotes and plants, where they appear to control a few very specific functions. Two-component systems have evolved in Bacteria from much simpler one-component systems bringing about the benefit of extracellular versus intracellular sensing. We review reports establishing the origins of two-component systems and documenting their occurrence in major lineages of Life.
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