Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 11, Issue 2, Pages 141-147Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2008.02.015
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM070768] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM070768-01, R01 GM070768-02, GM70768, R01 GM070768-04, R01 GM070768-03, R01 GM070768] Funding Source: Medline
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Our understanding of the accuracy of tRNA selection on the messenger RNA programmed ribosome has recently increased dramatically because of high-resolution crystal structures of the ribosome, cryo-electron microscopy reconstructions of its functional complexes, and fast kinetics experiments. Application of single-molecule spectroscopy with fluorescence resonance energy transfer to studies of tRNA selection by the ribosome has also provided new, albeit controversial, insights. Interestingly, when the fundamental trade-off between rate and accuracy in substrate-selective biosynthetic reactions is taken into account, some aspects of the current models of ribosome function appear strikingly suboptimal in the context of growing bacterial cells.
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