Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 11, Issue 2, Pages 134-140Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2008.02.003
Keywords
-
Categories
Funding
- NIGMS NIH HHS [R01 GM023037-20, R01 GM023037, R01 GM023037-21, 2-R01-GM23037, R01 GM023037-22] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM023037] Funding Source: NIH RePORTER
Ask authors/readers for more resources
The posttranscriptional modification of RNA is a significant investment in genes, enzymes, substrates, and energy. Advances in molecular genetics and structural biology indicate strongly that modifications of tRNA's anticoclon domain control gene expression. Modifications at the anticodon's wobble position are required for recognition of rarely used codons and restrict or expand codon recognition depending on their chemistries. A shift of the translational reading frame occurs in the absence of modifications at either wobble position-34 or the conserved purine-37, 3'-adjacent to the anticodon, causing expression of alternate protein sequences. These modifications have in common their contribution of order to tRNA's anticodon.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available