Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 11, Issue 2, Pages 78-86Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2008.02.005
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Funding
- NATIONAL LIBRARY OF MEDICINE [G13LM008297] Funding Source: NIH RePORTER
- NLM NIH HHS [G13 LM008297-01, G13 LM008297-03, G13 LM008297-02] Funding Source: Medline
- PHS HHS [HHSSN266200400042C] Funding Source: Medline
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Survival and replication of most bacteria require the ability to synthesize the amino acid L-tryptophan whenever it is not available from the environment. In this article we describe the genes, operons, proteins, and reactions involved in tryptophan biosynthesis in bacteria, and the mechanisms they use in regulating tryptophan formation. We show that although the reactions of tryptophan biosynthesis are essentially identical, gene organization varies among species-from whole-pathway operons to completely dispersed genes. We also show that the regulatory mechanisms used for these genes vary greatly. We address the question-what are some potential advantages of the gene organization and regulation variation associated with this conserved, important pathway?.
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