4.6 Review

Macrolide myths

Journal

CURRENT OPINION IN MICROBIOLOGY
Volume 11, Issue 5, Pages 414-421

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2008.08.003

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Funding

  1. National Science Foundation [MCB-0515934]
  2. National Institutes of Health [AI072445]
  3. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI072445] Funding Source: NIH RePORTER

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In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'. This review focuses on certain aspects of binding and action of macrolides that may need re-evaluation in view of the new findings.

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