4.3 Review

Atherosclerotic lesions in mouse and man: is it the same disease?

Journal

CURRENT OPINION IN LIPIDOLOGY
Volume 21, Issue 5, Pages 434-440

Publisher

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e32833ded6a

Keywords

animal model; atherosclerosis; hypercholesterolemia; transgenesis

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Murine atherosclerosis models are highly valuable for identifying atherogenic mechanisms that can be targeted by preventive medicine. However, models with thrombotic complications and large animal models suitable for interventional procedures and imaging would be more supportive for current clinical practice and are highly wanted.

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