Journal
CURRENT OPINION IN LIPIDOLOGY
Volume 19, Issue 5, Pages 505-512Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOL.0b013e32830d81e9
Keywords
angiogenesis; endothelial progenitor cells; Kruppel-like factor; nuclear factor - erythroid 2 related factor; vascular endothelial growth factor
Funding
- Foundation for Polish Science
- Ministry of Science and Higher Education [N301 08032/3156, N-401-120/32/ 2422, PBZ-KBN 106/P05/2004, 512/6.PR UE/2008/7]
- European Vascular Genomics Network [LSHM-CT 2003-503254]
- European Commission
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Purpose of review Heme oxygenase-1 apart from converting heme to carbon monoxide, iron and biliverdin has been shown to exert anti-inflammatory, antiapoptotic and antioxidant actions The. present review summarizes the most recent studies about heme oxygenase-1 involvement in atherosclerosis, neovascularization and endothelial progenitor cells biology. Recent findings Heme oxygenase-1 has been shown to be protective against atherosclerosis via decreasing ROS generation and proinflammatory cytokine production resulting in diminished lipid uptake and foam cell formation. Moreover, heme oxygenase-1 role in neovascularization and its involvement in response of endothelial progenitor cells to stromal cell derived factor-1 as well as endothelial cells to vascular endothelial growth factor has been stressed, recently. The detailed mechanisms of heme oxygenase-1 action in the processes of vasculogenesis and angiogenesis as well as the involvement of Nrf2 and KLF2 transcription factors in heme oxygenase-1-dependent vascular protection are among the subjects most intensively studied, currently. Summary Recent studies underscore the critical role of heme oxygenase-1 in neovascularization, implicating heme oxygenase-1 as an attractive therapeutic target for treatment of cardiovascular disease.
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