Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 26, Issue -, Pages 140-146Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.12.001
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Funding
- NIAID NIH HHS [R37 AI067497, R56 AI067497] Funding Source: Medline
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The differentiation and activation of both innate and adaptive immune cells is highly dependent on a coordinated set of transcriptional and post-transcriptional events. Chromatin-modifiers and transcription factors regulate the accessibility and transcription of immune genes, respectively. Immune cells also express miRNA and RNA-binding proteins that provide an additional layer of regulation at the mRNA level. However, long noncoding RNAs (IncRNAs), which have been primarily studied in the context of genomic imprinting, cancer, and cell differentiation, are now emerging as important regulators of immune cell differentiation and activation. In this review, we provide a brief overview of IncRNAs, their known functions in immunity, and discuss their potential to be more broadly involved in other aspects of the immune response.
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