Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 29, Issue -, Pages 127-136Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.06.007
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Funding
- US National Institutes of Health, National Institute of Allergy and Infectious Diseases [T32 AI007517, U19 AI089992, 272201100019C-3-0-1]
- National Institute on Aging [K24 AG042489]
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HIV infection is associated with a chronic inflammatory state arising from multiple factors, including innate immune recognition of HIV, increased microbial translocation, and release of endogenous ligands from damaged cells (such as CD4 T cells). In many respects, this heightened pro-inflammatory environment resembles that associated with aging in the absence of HIV infection, and evidence of dysregulated innate immune responses can be found in not only older HIV-negative adults, but also adults with HIV infection. While the study of innate immune aging in HIV infection is still in its early stages, it seems likely that at least additive, or potentially synergistic effects of aging and HIV infection will be found.
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