Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 30, Issue -, Pages 54-62Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.07.003
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Funding
- Yael and Rami Ungar, Israel
- Abisch Frenkel Foundation for the Promotion of Life Sciences
- Gurwin Family Fund for Scientific Research
- Leona M. and Harry B. Helmsley Charitable Trust
- Crown Endowment Fund for Immunological Research
- Estate of Jack Gitlitz
- Estate of Lydia Hershkovich
- European Research Council [615265]
- Boehringer Ingelheim Fonds PhD Fellowship
- European Research Council (ERC) [615265] Funding Source: European Research Council (ERC)
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The human meta-organism consists of more than 90% of microbial cells. The gastrointestinal tract harbors trillions of commensal microorganisms that influence the development and homeostasis of the host. Alterations in composition and function of the microbiota, termed dysbiosis, have been implicated in a multitude of metabolic and inflammatory diseases in humans. Thus, understanding the molecular underpinnings the cross talk between commensal bacteria and their host during homeostasis and dysbiosis may hold the key to understanding many idiopathic diseases. While most attention has focused on the innate recognition of immune-stimulatory bacterial molecules, such as cell wall components and nucleic acids, we emphasize here the impact of diet-dependent microbial metabolites on the development and function of the immune system.
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