Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 30, Issue -, Pages 48-53Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.06.006
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Funding
- National Creative Research Initiative Program from National Research Foundation of South Korea and Samsung Science & Technology Foundation [20120000231, SSTF-BA1401-15]
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The metabolic activities of a given gut bacterium or gut commensal community fluctuate in a manner largely depending on the physicochemical parameters within the gut niche. Recognition of the bacterial metabolic status in situ, by a sensing of the gut metabolites as a signature of a specific bacterial metabolic activity, has been suggested to be a highly beneficial means for the host to maintain gut-microbe homeostasis. Recently, analysis of Drosophila gut immunity revealed that bacterial-derived uracil and uracil-modulated intestinal reactive oxygen species (ROS) generation play a pivotal role in diverse aspects of host microbe interactions, such as pathogen clearance, commensal protection, intestinal cell regeneration, colitogenesis, and possibly also interorgan immunological communication. A deeper understanding of the role of uracil in Drosophila immunity will provide additional insight into the molecular mechanisms underlying host microbe symbiosis and dysbiosis.
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