Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 29, Issue -, Pages 56-61Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.04.002
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Funding
- Spanish Ministry of Health [PS09/00723, PI13/02691]
- Ministry of Science and Innovation of Spain [SAF2009-09711]
- Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
- Junta de Extremadura [GRU10104]
- University of Extremadura - European Regional Development Fund (FEDER)
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NK cells are key players in the innate immune response against virus infection and tumors. Here we describe the current knowledge on age-associated changes in NK cells and the role of persistent CMV infection in configuring NK cell compartment in the elderly. Aging but not CMV causes a redistribution of NK cell subsets as shown by a decrease of CD56bright cells and an increase of CD56-CD16+ NK cells. On the contrary the changes in CD56dimCD16+ NK cells are compatible with the accumulation of CD57+ long-lived NK cells that can also be observed in young CMV-seropositive individuals. NK cell function and dynamics in the elderly will be related not only with age but also with exposure to pathogens, especially CMV.
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