Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 26, Issue -, Pages 14-20Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.10.009
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Funding
- Division of Intramural Research
- NIAID
- NIH
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Pattern recognition receptors (PRRs) are essential sentinels for pathogens or tissue damage and integral components of the innate immune system. Recent structural studies have provided unprecedented insights into the molecular mechanisms of ligand recognition and signal transduction by several PRR families at distinct subcellular compartments. Here we highlight some of the recent discoveries and summarize the common themes that are emerging from these exciting studies. Better mechanistic understanding of the structure and function of the PRRs will improve future prospects of therapeutic targeting of these important innate immune receptors.
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