Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 28, Issue -, Pages 77-83Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2014.02.009
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Funding
- Deutsche Forschungsgemeinschaft [SFB-650, TRR-36, TRR-130, FI-1238/02]
- Hertie Stiftung
- Merieux Institute
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B lymphocytes have a unique role as antibody-producing cells. Antibodies are key mediators of humoral immunity against infections, and are thought to account for the protection afforded by successful vaccines. B cells can also secrete cytokines and subsequently regulate immune responses mediated by T and innate cells. Remarkably, recent studies identified plasma blasts/plasma cells as the main types of activated B cells producing the cytokines interleukin (IL)-10, IL-35, tumor necrosis factor (TNF)-alpha, IL-17, and GM-CSF in various contexts in mice. Here, we discuss these observations, which suggest the existence of various subsets of plasma blast/plasma cells distinguishable through their cytokine expression pattern.
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