Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 2, Pages 261-267Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.03.004
Keywords
-
Categories
Funding
- Institut National du Cancer (INCa)
- Canceropole Ile de France
- INSERM
- MedImmune
- Qatar National Research Fund under its National Priorities Research Program [NPRP09-1174-3-291]
- European Commission (Geninca Consortium) [202230]
- LabEx Immuno-oncology
Ask authors/readers for more resources
The inherent complexity of multifactorial diseases such as cancer renders the process of patient prognosis and prediction of response to therapy extremely difficult. Many markers, signatures, and methods have been described to evaluate the prognosis of cancer patients, yet very few translate into the clinic. Systems biology approaches have facilitated analysis of the complex interaction between tumors and the host-immune response, and allowed the definition of the immune contexture. Here we review the potential of the immune contexture, quantified by the Immunoscore, to provide a statistically strong parameter for prognosis. Finally we introduce the concept that the host-immune reaction could be the critical element in determining response to therapy. The effect on the immune response could be the underlying factor behind many of the predictive markers.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available