Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 3, Pages 381-388Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.03.003
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Funding
- National Institutes of Health [R01 AI030048, P01 A1080192]
- Irvington Institute Fellowship Program of the Cancer Research Institute
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PD-1 is an inhibitory receptor induced in T cells by antigen stimulation and sustained PD-1 expression plays a key role in T cell dysfunction. Blocking PD-1 signaling rescues exhausted T cells and is an effective treatment for chronic infections and cancer. Nonetheless, combining PD-1 pathway blockade to therapeutic vaccination should further improve T cell rescue. PD-1 is induced shortly after T cell priming, but little is known about the role of PD-1 in the initiation of immune responses. In addition, the PD-1 pathway may also modulate humoral responses, since both B cells and Tfh cells express PD-1. Therefore, even though much progress has been achieved by manipulation of the PD-1 pathway to rescue exhausted T cells, this powerful immunotherapy could still be further exploited.
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