Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 1, Pages 34-39Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.11.009
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Funding
- National Institute of Allergy and Infectious Diseases [AI095396, AI08972]
- National Institute of Health [AI007328-25]
- Stanford University
- German Research Foundation (DFG) [Ko 4584/1-1]
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Pattern recognition receptors recognize signals originating from pathogens and comprise a large part of the arsenal in innate immune responses. The NOD-like receptors (NLRs) are one particular class of these receptors that survey the cytoplasm for signs of pathogen invasion. Upon detection, they trigger the formation of a nnacromolecular complex called the inflamnnasome that is required for elimination of the pathogen, as well as amplifying a pro-inflammatory response. Although the core machinery has been defined, recent data emphasize the complexity of how NLR inflammasomes function. Here, we highlight new discoveries that reveal how precisely fine-tuned NLR inflammasome functions are, and how that may be modulated by antagonistic effects of concomitant inflammasome activation as well as novel regulatory factors.
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