Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 3, Pages 410-417Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.02.004
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- NIDDK NIH HHS [R01 DK067180] Funding Source: Medline
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Recent interest in testing whether the success of antigen-specific immunotherapy (ASIT) for autoimmune diseases in mice can be translated to humans has highlighted the need for better tools to study and understand human autoimmunity. Clinical development of ASIT for allergy has been instructive, but limited understanding of CD4 T cell epitope/determinant hierarchies hampers the rational design and monitoring of ASIT. Definitive identification of pathogenic T cell epitopes as is now known in celiac disease and recent initiatives to optimize immune monitoring will facilitate rational design, monitoring and mechanistic understanding of ASIT for human autoimmune diseases.
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