Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 4, Pages 428-435Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.05.012
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Funding
- National Institutes of Health [AI046629, DK32520, CA034196]
- University of Massachusetts Center for AIDS Research [P30 AI042845]
- Helmsley Charitable Trust
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Many of the pathogens that cause human infectious diseases do not infect rodents or other mammalian species. Small animal models that allow studies of the pathogenesis of these agents and evaluation of drug efficacy are critical for identifying ways to prevent and treat human infectious diseases. Immunodeficient mice engrafted with functional human cells and tissues, termed 'humanized' mice, represent a critical preclinical bridge for in vivo studies of human pathogens. Recent advances in the development of humanized mice have allowed in vivo studies of multiple human infectious agents providing novel insights into their pathogenesis that was otherwise not possible.
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