Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 25, Issue 5, Pages 593-597Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2013.09.013
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Funding
- NIAID [R00 AI085035]
- NIH [AI066897, AI068129, CA095137]
- NIH/NIAID [R24-AI072073]
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The Immunological Genome Consortium has generated a public resource (www.immgen.org) that provides a compendium of gene expression profiles of similar to 270 leukocyte subsets in the mouse. This effort established carefully standardized operating procedures that resulted in a transcriptional dataset of unprecedented comprehensiveness and quality. The findings have been detailed recently in a series of publications providing molecular insights into the development, heterdgeneity, and/or function of these cellular lineages and distinct subpopulations. Here, we review the key findings of these studies, highlighting what has been gained and how the knowledge can be used to accelerate progress toward a comprehensive understanding of the immune system.
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