Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 24, Issue 4, Pages 482-487Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.04.005
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Funding
- Public Health Service [AG033057, AI057753]
- Ellison Medical Foundation/AFAR
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A hallmark of aging is the progressive deterioration of immune function. Age-related immune suppression increases susceptibility to infectious diseases and cancer, significant causes of morbidity and mortality in the elderly. In particular, age-related T cell dysfunction is a major contributor to 'immune-senescence'. Recently, it has become clear that the frequency of regulatory T cells (Treg) significantly increases in aged mice and humans. As Treg control the intensity of T cell responses, their accrual probably contributes to age-related immune dysfunction. This review will focus on mechanisms underlying Treg homeostasis and function in aging.
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