Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 24, Issue 2, Pages 178-183Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.02.003
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Funding
- Institut Pasteur
- Agence Nationale de la Recherche
- Fondation de la Recherche Medicale
- Fondation Simone e Cino Del Duca
- European Commission
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Lymphoid tissue inducer (LTi) cells are programmed by the mammalian fetus to induce the development of lymph nodes and Peyer's patches. LTi cells share a pro-inflammatory profile with Th17 cells, as well as their requirement for the transcription factor ROR gamma t. We discuss here the latest data on the fetal and post-natal development of LTi cells, and their relationship with the larger family of innate lymphoid cells (ILCs). We suggest that the re-programming of ROR gamma t in a subset of common lymphoid progenitors allowed mammals to develop lymphoid organs before birth, whereas other vertebrates only develop such organs in response to infection or injury.
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