Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 24, Issue 6, Pages 686-691Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2012.07.011
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Funding
- National Institutes of Health [AI47859]
- Lupus Research Institute
- Andrew J. Semesco Foundation
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The role of microRNAs (miRNAs) in the regulation of many physiological and pathological processes has been intensely studied in recent years. Some miRNAs, such as miR-146a and miR-182, play a dominant role in the regulation of the innate and adaptive immune responses, respectively. Many miRNAs are reportedly deregulated in autoimmune diseases, but miR-146a in particular seems to be consistently altered. The overexpression or underexpression of miRNAs can influence specific targets and pathways, leading to autoimmune disease phenotypes, and this is supported also by some in vivo studies. Targeting miRNAs could represent a valid future therapeutic option for autoimmune diseases.
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