Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 24, Issue 2, Pages 132-138Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.12.012
Keywords
-
Categories
Funding
- USPHS [R01AI083514, R01AI095943, RC2CA148278]
- Albert Billings Ruddock Professorship
Ask authors/readers for more resources
The T-cell development program is specifically triggered by Notch-Delta signaling, but most transcription factors needed to establish T-cell lineage identity also have crossover roles in other hematopoietic lineages. This factor sharing complicates full definition of the core gene regulatory circuits required for T-cell specification. But new advances illuminate the roles of three of the most T-cell specific transcription factors. Commitment to the T-cell lineage is now shown to depend on Bcl11b, while initiation of the T-cell differentiation program begins earlier with the induction of TCF-1 (Tcf7 gene product) and GATA-3. Several reports now reveal how TCF-1 and GATA-3 are mobilized in early T cells and the pathways for their T-lineage specific effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available