Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 1, Pages 65-70Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.10.010
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Funding
- Ministry of Education, Science and Technology [R13-2007-020-01000-0]
- NIH [AI073539, AI047868, AI022553]
- Deutsche Forschungsgemeinschaft [FA849/1-1, FA849/2-1]
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There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves complex pathways including signaling molecules that have widespread roles in cell biological functions. For example, inhibiting mTOR by rapamycin, the most widely used chemical approach to induce autophagy, can also result in immunosupression. Nevertheless, advances in our understanding of autophagy provide a new opportunity to modulate host cellular responses at; a potential therapeutic strategy to combat microbial infections in humans.
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