Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 4, Pages 495-499Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.06.003
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Funding
- National Institute of Health [AI083481, AI083284]
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Type I IFNs are well known for their role in controlling virus replication and spread. Type I IFNs produced by the infected tissue also signal beyond the boundaries of the infection to regulate different elements of the anti-viral immune response. Recent reports show that type I IFNs directly condition naive monocytes residing in the distal bone marrow (BM) and induce the expression of effector molecules in memory T cells, before their recruitment to the infected site. In addition, hematopoietic stem cells (HSCs) were shown to enter the cell cycle in response to systemically distributed type I IFNs. These discoveries expand our understanding of the pleiotropic effects of type I IFNs during infection and highlight the critical role of systemic signals in the development of an effective response to a localized viral infection.
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