Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 2, Pages 220-227Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.12.016
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Funding
- NIH [R01AI059739, R01AI083988]
- Ruth L. Kirschstein NRSA [F31CA130744]
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Recent studies have shown that the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) controls the development of essentially all of the innate-like features of invariant Natural Killer T (NKT) cells. For example, PLZF-deficient NKT cells do not acquire an 'activated' phenotype nor do they acquire the capacity to secrete multiple cytokines upon primary stimulation. The function of a subset of gamma delta T cells has now also been shown to be dependent upon expression of PLZF. Furthermore, IL-4 produced by PLZF-expressing cells causes some CD8 T cells to acquire innate-like features. Therefore, it is becoming clear that PLZF has a broad impact on the immune response. Here we discuss the current understanding of how expression of PLZF, the innate T cell determinant, is initiated during T cell development.
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