Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 6, Pages 721-731Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.10.007
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Funding
- NIH [AI076505, AR058481, AI064930]
- Alliance for Lupus Research
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There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B cells and clonal ignorance mediated by the SIAE/Siglec pathway will be reviewed.
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