Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 4, Pages 543-548Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.05.001
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- INSERM
- ANR
- ANRS
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The thymus is responsible for the maturation of lymphoid precursors into T cells, and is necessary to establish the T cell pool during prenatal and early postnatal life in humans. With the years, it undergoes a natural shrinking process, referred to as involution, suspected to be central in the decline of immune competence with aging, or immunosenescence. Here, we review the recent studies focusing on the immunological consequences of abnormal thymic development and thymectomy shortly after birth. These works highlight the importance of the thymic function in preserving immune efficacy throughout life, and provide insights into the development of immune aging.
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