Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 23, Issue 4, Pages 487-494Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2011.05.010
Keywords
-
Categories
Funding
- National Institutes of Health (National Heart, Lung, and Blood Institute and National Institute of Allergy and Infectious Diseases)
Ask authors/readers for more resources
Research on the pathogenesis of asthma has concentrated on initial stimuli, genetic susceptibilities, adaptive immune responses, and end-organ alterations (particularly in airway mucous cells and smooth muscle) as critical steps leading to disease. Recent evidence indicates that the innate immune cell response to respiratory viruses also contributes to the development of inflammatory airway disease. We further develop this concept by raising the issue that the interaction between host airway epithelial cells and respiratory viruses is another aspect of innate immunity that is also a critical determinant of asthma. We also introduce a rationale for how antiviral performance at the epithelial cell level might be improved to prevent acute infectious illness and chronic inflammatory disease caused by respiratory viruses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available