Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 4, Pages 507-513Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.05.003
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Funding
- National Institute on Aging [AG019134]
- National Institute for Allergy and Infectious Disease [NO150031]
- Biotechnology and Biological Sciences Research Council
- Medical Research Council [G9818340B] Funding Source: researchfish
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The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like Receptors. However, aging is also characterized by a constitutive pro-inflammatory environment (inflamm-aging) with persistent low-grade innate immune activation that may augment tissue damage caused by infections in elderly individuals. Thus, immunosenescence in the innate immune system appears to reflect dysregulation, rather than exclusively impaired function.
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