Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 2, Pages 177-184Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.02.003
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Funding
- NIH [T32 AI07405, R01 AI54661, P01 AI22295, R21 AI075177]
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The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific transcription factors that progressively direct cell fate choices. Differentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage priming and graded levels of PU.1, which are controlled by Ikaros and Gfi1. E2A drives expression of EBF1, which initiates B lineage specification. EBF1, in addition to Pax5, is necessary for commitment to the B cell lineage. As a model of gene activation in early B lymphopoiesis, mb-1 genes are activated sequentially by factors (e.g. EBF1) that initiate chromatin modifications before transcription. This review highlights the requisite interplay between transcription factors and epigenetic mechanisms in the context of B cell development.
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