Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 3, Pages 358-366Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.02.012
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Funding
- NIAID
- International AIDS Vaccine Initiative
- Ragon Institute of MGH, MIT, and Harvard
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI033292, R37AI055332] Funding Source: NIH RePORTER
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Many antiviral vaccines elicit neutralizing antibodies as a correlate of protection. For HIV, given the huge variability of the virus, it is widely believed that the induction of a broadly neutralizing antibody (bNAb) response will be crucial in a successful vaccine against the virus. Unfortunately, despite many efforts, the development of an immunogen that elicits bNAbs remains elusive. However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.
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