Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 3, Pages 402-410Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.04.002
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Funding
- Intramural NIH HHS [Z01 AI000542-20] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000658, ZIAAI000542] Funding Source: NIH RePORTER
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CD8+ T cells play important roles in clearing viral infections and eradicating tumors. Designing vaccines that elicit effective CD8+ T cell responses requires a thorough knowledge of the pathways of antigen presentation in vivo. Here, I review recent progress in understanding the activation of naive CD8+ T cells in vivo, with particular emphasis on cross-priming, the presentation of protein antigens acquired by dendritic cells from their environment. With the rapid advances in this area of research, the dawn of rational vaccine design is at hand.
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